Abstract:
In this study, we aimed to investigate the relationship
between the cytotoxic and dielectric properties of
newly synthesized 2,2,4,4-tetra(4′-oxy-substituted-chalcone)-
6,6-diphenylcyclotriphosphazene derivatives (3–10). Firstly,
2,2,4,4-tetrachloro-6,6-diphenyl cyclotriphosphazene (2) was
obtained through Friedel Crafts alkylation in the presence of
hexachlorocyclotriphosphazene, benzene and triethylamine
and anhydrous AlCl3. The compounds 3–10 were synthesized
from the reaction of the hydroxychalcone compounds
(1a–h) with 2 in the presence of K2CO3 and within the
acetone solvent for the first time and their dielectric constant,
dielectric loss factor and ac conductivity of compounds 3–10
were examined through the impedance analyzer as a function
of frequency. The in vitro cytotoxic activities of compounds
3–10 in five different concentrations (1, 5, 25, 50, and 100
µM) were analyzed by colorimetric MTT assay which is
based on reduction of MTT salt by mitochondria of alive
cells over the human ovarian cancer (A2780) and human
prostate cancer (PC-3 and LNCaP) cell lines. The LogIC50
values of 3–10 were calculated by using a Graphpad prism 6
programs on a computer. The obtained results suggests that the compounds have a powerful cytotoxic activity (especially
A2780, p < 0.05).
