Özet:
The aim of this studywasto investigate the possible protective effects of lycopene (LC) and ellagic acid (EA)
on cisplatin (CP)-induced testicular apoptosis in male rats. The control group was treated with placebo;
LC, EA and CP groups were given alone LC, EA and CP, respectively; the CP + LC group was treated with a
combination of CP and LC; and the CP + EAgroup was treated with a combination of CP and EA. Although CP
significantly increased the number of Bax-positive (apoptotic) cells it had no effect on the number of Bcl-
2-positive (antiapoptotic) cells compared with the control group. Administration of CP caused significant
increase in lipid peroxidation and nonsignificant decrease in superoxide dismutase (SOD) activity along
with some histopathological lesions in testicular tissue. However, combined treatments of LC or EA in
addition to CP tended to prevent the CP-induced testicular apoptosis, histopathological lesions and lipid
peroxidation.
