SPOR BİLİMLERİ FAKÜLTESİ

Effect of short term match program on certain blood lipids of football players

Tue, 01 Jan 2013 00:00:00 GMT

Effect of short term match program on certain blood lipids of football players Cengiz, Şebnem; Çınar, Vedat; Pala, Ragıp; Dündar, Aykut Purpose: In this study, it is aimed to determine the effect of match program of 10 days and in chronic medium intensity on the Triglyceride, Cholesterol, HDL and LDL blood values of football players. Instruments and Methods: Research is performed on 18 healthy male footballer subjects. All subjects participated in match program for total of 7 days, 90 minutes on one day within the framework of a 10 days match program. Blood samples were taken from all subjects in resting position before starting to the match program and 2 hours after the end of the last match. Triglyceride, Cholesterol, HDL and LDL levels were specified in the blood samples received. Findings: According to the data obtained at the end of the match program, triglyceride level has decreased significantly in comparison to the values before the match program (p<0.05). Same result was obtained for the cholesterol levels, similarly blood values taken at the end of the match program as the posttest measurements were lower than the pretest measurements, thus the difference between was statistically important (p<0.05).At the end of the match program, there was a significant decrease in the posttest measurements of LDL in comparison to the pretest measurements (p>0.05). It is determined that HDL values after the match recorded an increase in comparison to the values before the match. Thus, the difference between is statistically significant (p<0.05). Results: According to the results of the study, short-term match program caused changes in the Cholesterol, HDL and LDL blood values.

Examining certain blood parameters of sporters of national boxing team before and after the match

Tue, 01 Jan 2013 00:00:00 GMT

Examining certain blood parameters of sporters of national boxing team before and after the match Pala, Ragıp Research group of this study consists of total 10 boxers who are actively involved in Turkish big male national boxing team and with average age of 22.40 age/years. Blood samples were taken twice from boxers constituting the research group before and after the match after the camp program of eight weeks applied for research group. Data and laboratory results are utilized as covariant. Relative changes in the data obtained are analyzed by SAS package program and by utilizing PROC MEANS procedure. Significance level of changes observed is specified by Paired t test that adds significance at the level of P<0.05. Statistically significant increase is observed in the glucose levels of boxers as one of the blood parameters before and after the match (P=0.0014). Decrease in the insulin levels is determined before and after the match, however it is not found statistically significant (P=0.1059). It is observed that cortisol levels have increased before and after the match, however it is not considered statistically meaningful (P=0.0534). Decrease in the urea levels is determined before and after the match, however the difference is not found statistically significant. (P=0.5837). Differences in the creatine levels before and after the match are found to be insignificant (P=0.0815). According to the results of the research, important changes in all blood parameters of sporters of national boxing team are observed before and after the match, however statistically significant difference is observed only in glucose parameter. Thus, it can be stated that our application caused significant changes only in the glucose parameter among the parameters we examined.

Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model

Fri, 01 Jan 2016 00:00:00 GMT

Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model Şahin, Kazım; Pala, Ragıp; Tuzcu, Mehmet; Özdemir, Oğuzhan; Orhan, Cemal; Şahin, Nurhan; Juturu, Vijaya Purpose Exercise (Ex) increases reactive oxygen species and impairs antioxidant defense systems. Recent data suggest that curcumin (CW) possesses peroxisome proliferator-activated receptor gamma activity and anti-inflammatory properties. Therefore, this study was designed to investigate the effects of CW supplementation on Ex performance, endurance, and changes in serum and muscle proteins in rats after exhaustive Ex. Materials and methods Twenty-eight (28) male Wistar rats (age: 8 weeks and body weight: 180±20 g) were divided into four treatment groups: 1) control (C; no Ex), 2) C + CW (no Ex + CW), 3) C + Ex, and 4) C + Ex + CW (Ex + CW). CW was administered as 100 mg/kg CurcuWin®, providing 20 mg of curcuminoids daily for 6 weeks. A motor-driven rodent treadmill was used to carry out the Ex protocols. During a 5-day period, animals in chronic Ex groups were put through different regimens: day 1, 10 m/min for 10 minutes; day 2, 20 m/min for 10 minutes; day 3, 25 m/min for 10 minutes; day 4, 25 m/min for 20 minutes; and day 5, 25 m/min for 30 minutes. Animals were exercised at 25 m/min for 45 min/d for 5 d/wk for 6 weeks. Blood and muscle samples were analyzed for muscle markers, oxidative stress, and antioxidant markers. Results Lactate and muscle malondialdehyde levels decreased in the CW-treated groups (P<0.0001). However, activities of antioxidant enzyme levels increased in the CW-treated groups. Run to exhaustion (minutes) improved in the CW-treated groups. Muscle nuclear factor-κB (P<0.05) and heat shock protein 70 (P<0.05) levels were much lowered in the CW treated group followed by Ex group. In addition, muscle inhibitors of kappa B, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, thioredoxin-1, sirtuin 1, nuclear factor (erythroid-derived 2)-like 2, and glucose transporter 4 protein levels in the Ex + CW group were higher than those in the control and Ex groups (P<0.05). Conclusion This study suggests that novel CW has the potential to help prevent muscle damage by regulating the nuclear factor-κB and nuclear factor (erythroid-derived 2)-like 2 pathways and improve the performance and nutritional values of CW.

Coenzyme Q10 supplementation modulates NFκB and Nrf2 pathways in exer-cise training

Fri, 01 Jan 2016 00:00:00 GMT

Coenzyme Q10 supplementation modulates NFκB and Nrf2 pathways in exer-cise training Pala, Ragıp; Orhan, Cemal; Tuzcu, Mehmet; Şahin, Nurhan; Ali, Shakir; Çınar, Vedat; Atalay, Mustafa; Şahin, Kazım This study reports the effects of Q10, coenzyme Q10 or ubiqui-none, a component of the electron transport chain in mitochon-dria, on nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), inhibitors of kappa B (IκB), nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and hemeoxygenase 1 (HO-1) in rats after chronic exercise training for 6 weeks. 8-week old male Wistar rats were assigned randomly to one of four treat-ments planned in a 2 x 2 factorial arrangement of two condition (sedentary vs. exercise training), and two coenzyme Q10 levels (0 and 300 mg/kg per day for 6 weeks). The expression levels of the target proteins were determined in the heart, liver and mus-cle, and biochemical parameters including creatinine, urea, glucose and lipid profile were investigated in plasma. When compared with sedentary group, significant decreases in heart, liver and muscle NFκB levels by 45%, 26% and 44% were observed in Q10 supplemented rats after exercise training, re-spectively, while the inhibitory protein IκB increased by 179%, 111% and 127% in heart, liver and muscle tissues. Q10 supple-mentation caused an increase in Nrf2 (167%, 165% and 90%) and HO-1 (107%, 156% and 114%) after exercise training in heart, liver and muscle tissues (p < 0.05). No significant change was observed in any of the parameters associated with protein, carbohydrate and lipid metabolism, except that exercise caused a decrease in plasma triglyceride, which was further decreased by Q10. In conclusion, these results suggest that Q10 modulates the expression of NFκB, IκB, Nrf2 and HO-1 in exercise training, indicating an anti-inflammatory effect of Q10 and emphasizes its role in antioxidant defense.